SOX2 and neoplasm: Stanford et al. (29) determined that AhR controls cancer stemness in human TNBC Hs578T cells, as AhR knockdown decreases tumor sphere formation and in vivo tumor growth via downregulation of ALDH1A1 and SOX2. While these reports provide evidence that AhR plays an oncogenic role in triple-negative breast cancer, other studies describe opposite results.