It should be emphasized that the immunodynamic or tumor ecodynamic four-factor relationship (IFNγ)(pSTAT1)/(TGFβ)(pSTAT3) or (TGFβ)(pSTAT3)/(IFNγ)(pSTAT1) is a collective linkage behavior, not a single factor action or one-to-one interaction. This evidence concerns the gene IFNG and neoplasm.