Although numerous studies have demonstrated that IFNγ is the upstream signaling molecule of pSTAT1 (32, 42), my group’s previous work indicated that pSTAT1 expression peaked on the first day of infection with malarial parasites (43), whereas other groups demonstrated that IFNγ did not peak until the fifth day of Plasmodium infection (44). The gene discussed is IFNG; the disease is infection.