TNFRSF8 and lymphoma: Since HRS are likely derived from crippled CD30+ germinal center B lymphocytes rescued by apoptosis, we can speculate that a skewed expression of CK2 subunits might be present also in CD30+ B cells or might be necessary for acquired the Hodgkin-phenotype as compared with other lymphomas where usually both subunits are overexpressed (25, 36).