Another study revealed that NSUN2 activation maintained global m5C methylation of RNA, including TREX2, in tumor cells and stabilized TREX2 expression, consequently impeding the accumulation of cytoplasmic double-stranded DNA and blocking the activation of the cGAS-STING pathway, which facilitated tumorigenesis and PD-L1 immunotherapy resistance (14). The gene discussed is TREX2; the disease is neoplasm.