O-glycosylation mediated by C1GALT1 affects the invasion and metastasis of a variety of tumorsvia regulating receptor tyrosine kinase, and the expression of C1GALT1 is associated with a poor prognosis of cancer patients[26,32], suggesting that C1GALT1 plays a key role in the development and progression of cancer. Here, NTRK1 is linked to cancer.