In another study using pingyangmycin as an ICD inducer combined with PD-1 antibodies, PD-1 antibodies effectively enhanced the ICD-induced T-cell immunity, such as an increase in tumor-infiltrating CD8+ T cells, a decrease in the proportion of CD4+ T cells, and a reduction in the proportion of Tregs in the peripheral blood[31]. The gene discussed is CD4; the disease is neoplasm.