GSDMD and colitis: Besides, our previous study added another layer of complexity to the role of GSDMD in intestinal immunity[25], in which we found that GSDMD in intestinal macrophages regulated the onset of colitis and maintained intestinal immune homeostasis by modulating the cGAS-mediated inflammatory response, suggesting the importance of GSDMD in fine-tuning the immune response in the intestine and preventing excessive inflammation.