In the present study, based on multiple public datasets, we did not find significant differential expression of KCNQ1 between gastric cancer and normal tissues, but prognostic significance existed between gastric cancer patients dichotomized by high- and low-expression levels of KCNQ1, indicating the possible effects of posttranscriptional processing of KCNQ1 during gastric cancer progression. The gene discussed is KCNQ1; the disease is gastric cancer.