SNCA and synucleinopathy: The14-3-3 proteins are linked to synucleinopathy probably because 14-3-3proteins share physical and functional homology with beta-synucleinand are capable of binding to and inhibiting alpha-synuclein aggregationduring synucleinopathic progression.71,72 In additionto being a candidate biomarker for DAT, 14-3-3 proteins further supportalpha synuclein as a node in this CSF proteomics network.