For example, MAPK8 [18], AKT3 [19], MAPK signaling pathway [25] and p53 signaling pathway [26] are known biomarkers in brain tumors, while PIK3R1 [29], HLA-G [31], IKBKB [32], JAK-STAT signaling pathway [40] and Arginine and proline metabolism pathway [42] are known for asthma. This evidence concerns the gene IKBKB and brain neoplasm.