The unadjusted logistic regression found injury mechanism (p = 0.005), systolic blood pressure (p = 0.031), diastolic blood pressure (p = 0.026), heart rate (p < 0.001), GCS (p < 0.001), ISS (p < 0.001), SOFA (p < 0.001), white blood cell (p = 0.027), hemoglobin (p < 0.001), glucose (p < 0.001), prothrombin time(p < 0.001), EASIX (p < 0.001), subdural hematoma (p < 0.001), subarachnoid hemorrhage (p = 0.029), delayed axonal injury (p = 0.021), coagulopathy (p < 0.001) were related with the mortality (Table 2). Here, F2 is linked to blood coagulation disease.