For any gene that was up-regulated in tumors, if patients with relatively higher expression showed worse prognosis, then these genes could be categorized as “oncogene-like”, such as BRSK1 (Fig. 1c); in contrast, if higher expression led to better prognosis in cancer patients, such as RFX8 (Fig. 1d), then this gene would be categorized as “up-regulated-saver”. Here, RFX8 is linked to cancer.