EZH2 and cancer: As an example, DUXAP8, a long noncoding RNA that showed “oncogene-like” behavior in 5 cancer types, could recruit histone demethylase LSD1 and histone methyltransferase EZH2 to repress tumor suppressors [41, 42]; in addition, it could also suppress ferroptosis and induces drug resistance [43], thus functions in an “oncogene” manner.