LARS1 and infantile liver failure syndrome 1: Infantile liver failure syndrome type 1 (ILFS1; OMIM 615438) is a rare autosomal recessive disorder caused by pathogenic variants of the LARS1 gene (OMIM 151350) located on chromosome 5q32, which encodes leucyl-tRNA synthetase (LARS) and catalyzes the ligation of leucine to leucine tRNA [1].