THBD and Sepsis: A study using coagulation phenotypes as a secondary analysis of multicenter registries on sepsis patients admitted to the ICU, demonstrated that in one in four phenotypes, the one with high fibrinogen/fibrin-degradation-products and D-Dimer, treatment with thrombomodulin was associated with lower mortality (adjusted risk difference -18%, 95% CI -29%,-7%, n = 323) [43].