100% of models that included APOE e4/e4 (ORs = 1.56–8.76), 100% of models that included TBI (ORs = 3.42–14.48), 97% of models with hypertension (ORs = 0.97–4.54), and 93% depression outputs (ORs = 0.87–3.36) are positively associated (OR > 1) with dementia outcomes. This evidence concerns the gene APOE and major depressive disorder.