Moreover, the APOE e4/e4 ORs are significant among the late-life participants, displaying a different OR ranking and overall larger ORs compared to the midlife group in the age- and gender-adjusted models: AD (8.78 [7.29–10.57]), all-cause dementia (5.90 [5.13–6.78]), unattributed cause dementia (4.23 [3.31–5.40]), vascular dementia (4.19 [3.03–5.79]), and frontotemporal dementia (2.77 [1.12–6.86]). This evidence concerns the gene APOE and vascular dementia.