For example, in the age- and gender-adjusted model (Fig. 5), APOE e4/e4 has significant ORs, from high to low, in AD (5.09 [2.92–8.87]), all-cause dementia (3.85 [2.82–5.24]), and unattributed cause dementia (3.08 [1.93–4.9]) among the midlife participants. Here, APOE is linked to Alzheimer disease.