Consistent with SMAD2 being a transcription factor, we show no effect of SMAD2 KD on phosphorylation of NF-κB p65 but demonstrate the presence of a SMAD2/NF-κB complex in the cytoplasm and nucleus in TGF-β1-treated NB cells suggesting it could enhance the transcriptional activity of the NF-κB complex. Here, SMAD2 is linked to neuroblastoma.