Thus, the data indicates that TGF-β alters the sensitivity of NB cells to DOX and ETOP and the expression of MRP1, MDR1 and BCL-xL through a TAK1/NF-κB/SMAD2/3 pathway with TAK1 phosphorylating NF-κB and SMAD2 contributing to the NF-κB transcriptional complex. This evidence concerns the gene SMAD2 and neuroblastoma.