Notably, the canonical kinesin KIF5A, instrumental in the translocation of a myriad of neuronal cargo molecules, manifests a myriad of neuronal disorders, including ALS, upon its functional abrogation (Brenner et al, 2018; Naruse et al, 2021; Nicolas et al, 2018). The gene discussed is KIF5A; the disease is amyotrophic lateral sclerosis.