Recent evidence indicates that Insig1 expression is downregulated in kidney diseases such diabetic kidney disease (DKD) and renal mass loss (Kim et al, 2009; Liu et al, 2022), but no study has been done to determine the effect of Insig1 deficiency in the pathophysiology of CKD or PTCs fibrosis. The gene discussed is INSIG1; the disease is chronic kidney disease.