ERBB3 has a somatic mutation frequency of 2.1% in pan-cancer analysis with relatively high frequencies observed e.g. in urothelial (7.3–9.8%), endometrial (8.2–12.8%), lung (1.4–8.8%), and colorectal (5.4–6.2%) cancer (cbioportal.org) [23, 24]. The gene discussed is ERBB3; the disease is cancer.