E2F1 and osteoarthritis: Additional examples include hsa_circ_001783, which impacts breast cancer progression by sponging miR-200c-3p30, circCAMSAP1, which enhances tumor growth in colorectal cancer through the miR-328-5p/E2F1 Axis31, circEHBP1, which contributes to lymphangiogenesis and lymphatic metastasis in bladder cancer via miR-130a-3p/TGFβR1/VEGF-D signaling5,6, and circRNA.33186, which is implicated in the pathogenesis of osteoarthritis by sponging miR-127-5p32.