In vitro and in vivo studies have confirmed that P4HA2 can regulate the PI3K/Akt/mTOR signaling pathway to promote the occurrence and development of liver cancer17.Similarly to P4HA2, P4HA3 can mediate clear cell renal cell carcinoma progression by regulating the PI3K/AKT/GSK3β pathway18. This evidence concerns the gene P4HA2 and clear cell renal carcinoma.