ANGPT2, by binding to the TEK receptor, activates downstream signaling pathways, such as the PI3K/AKT pathway; the ANGPT2/TEK signaling axis is also involved in regulating the tumor microenvironment, including promoting inflammatory responses and attracting immune cells, such as macrophages, which affect tumor behavior by secreting factors that promote tumor growth and metastasis60. The gene discussed is TEK; the disease is neoplasm.