In addition to TEK, ANGPT2 can also interact with ITGA5_ITGB1, activating the TGFB-ZEB1-GLUT3 signaling pathway, accelerating physiological activities related to glycolytic metabolism in lung cancer cells, thereby causing tumor cells to prefer glycolytic metabolic pathways and accelerating tumor development61. Here, TGFB1 is linked to lung carcinoma.