IL6 and Sepsis: As a systemic inflammation disease, sepsis is highly associated with circulating inflammatory mediators such as high-sensitivity C-reactive protein (hs-CRP), interleukin (IL)-6, IL-8, etc. These pro-inflammatory mediators have impact on gap junction modulation and connexin dysregulation, calcium handling abnormalities and atrial fibrosis, which causes atrial action potential shortening, atrial ectopic activity triggering, atrial conducting slowing, and finally AF20.