HD patients treated with AHD showed significantly higher release of IFNγ, as compared with these treated with SHD (84.8 IQR 68.7–103.8 vs 33.5 IQR 19.7–51.1 mUI/mL, p = 0.014; Fig. 3). The gene discussed is IFNG; the disease is mitochondrial DNA depletion syndrome 4a.