Also, in this case HD patients treated with AHD showed stronger capacity (%) to release IFNγ after specific stimulus as compared to the maximum release induced by non-specific mitogen, while this ratio was significantly lower in HD patients treated with SHD (77.9 IQR 76.1–91.1% vs 32.2 IQR 17.8–52.0%, p < 0.001; Fig. 4). The gene discussed is IFNG; the disease is mitochondrial DNA depletion syndrome 4a.