Analyzing publicly available single-cell RNA sequencing (scRNAseq) data from human GBM35 showed the highest level and frequency of CXCL12 mRNA expression in endothelial cells, followed by pericytes, myeloid (macrophages, microglia), and glioma cells (Fig. 3a, Supplementary Fig. 4). This evidence concerns the gene CXCL12 and glioma.