CXCL12 and neoplasm: The mode of action of NOX-A12 strongly suggests that ongoing and uninterrupted treatment is crucial to prevent recurrence, as only the initial RT leads to devascularization of the tumor microenvironment, and an interruption of NOX-A12 infusions is likely to allow for rapid reconstitution of CXCL12 gradients and sequential vasculogenesis within few weeks30.