We then studied the expression of our proteins of interest in the hippocampus of the 3xTgAD mice that harbor an early and progressive accumulation of APP-CTFs starting at 2–3 months of age followed by the production and the accumulation of Aβ at 6 months of age and forming the amyloid plaques at 10–11 months of age [18, 27, 39]. Here, APP is linked to amyloidosis.