Strikingly and in line with STAT3β-deficient leukemia cells displaying attenuated commitment to the myeloid lineage, a significant decrease in CD11b expression and an increase of LSK blasts was detected upon IFNγ stimulation, which was stronger in leukemia cells lacking STAT3β (Fig. 5D, Supplementary Fig. 5C). The gene discussed is IFNG; the disease is leukemia.