In line with previous work demonstrating AML blasts themselves are capable of releasing IFNγ, associated with poorer OS [42], we detected Ifna, Ifnb and Ifng expression after 7 days in methylcellulose, with a significantly higher Ifng expression in colonies formed by STAT3β-deficient leukemia cells (Fig. 5F). Here, IFNA1 is linked to acute myeloid leukemia.