Besides lncRNAs, exercise-induced circular RNAs like circUtrn and circ-Ddx60 were recently shown to mediate cardioprotective effects as well.87,88 Of interest, in a mouse model of pathological cardiac hypertrophy, circ-Ddx60 was crucially involved in an antihypertrophic response of cardiac muscle tissue, which occurred after exercise hypertrophic preconditioning.87 This suggests a cardiac antihypertrophic memory after previous exercise training. Here, DDX60 is linked to cardiac hypertrophy.