Neuregulin 1 (NRG1), a growth factor involved in tissue development also functions as an exerkine in cardiac tissue as observed in a rat model of myocardial infarction, in which chronic moderate exercise induced the endothelial secretion of NRG1, favoring cardiac repair and regeneration by promoting DNA synthesis in adjacent cardiomyocytes via activation of Erb-B2 Receptor Tyrosine Kinase 2 and 4 (ERBB2 and ERBB4) receptor and downstream PI3K/AKT signaling.176. Here, NRG1 is linked to myocardial infarction.