STAT1 and chronic mucocutaneous candidiasis: Because IFN-γ receptor-deficient P14 T cells fail to generate functional effector or memory T cells28, we took a gain-of-function approach by examining the impact of ectopic expression in P14 T cells of wild-type STAT1 (STAT1WT) or STAT1R274W, a gain-of-function (GOF) STAT1 mutant associated in human patients with chronic mucocutaneous candidiasis (CMC)29.