Interestingly, transcript-level RNA-seq analysis revealed that SBNO2 represents the one confident IBD GWAS gene expressed in MDM (238 out of 280 (including SBNO2)) that shows IL-10-specific switching of isoform expression, while several other genes relevant to IBD show changes in transcript expression or usage upon LPS or LPS + aIL-10R stimulation of MDM (Fig. 1c). The gene discussed is SBNO2; the disease is inflammatory bowel disease.