SBNO2 and Crohn disease: Based on the analysis of genetic regulatory effects in 176 healthy donors steady state and LPS-stimulated monocytes we showed reduced SBNO2 expression, SBNO2 ISO2 expression, and SBNO2 ISO2 transcript usage upon LPS stimulation, providing a mechanistic basis for the association of genetic variation at the SBNO2 locus with Crohn’s disease.