To assess whether TAK-003–induced antibody and antigen profiles differ from those induced after natural infection and, therefore, may interfere with dengue diagnostics, the IgG and IgM antibody and NS1 antigen profiles were assessed in adults age 21 to 45 years living in Singapore (a dengue-endemic country) in a phase 2, double-blind, randomized study (#NCT02425098).15 The gene discussed is CD40LG; the disease is infection.