SIRPA and neoplasm: These results together support three conclusions for CIN-driven tumors: (1) increased survival attributed to anti-SIRPα supports the idea that CD47 modulates therapeutic outcome even during CIN; (2) increased survival attributed to anti-Tyrp1 highlights the importance of IgG opsonization; (3) maximal survival with the combination emphasizes that macrophages – which are skewed by CIN – play a key role in achieving near-complete rejection of tumor.