Importantly, comparing these sera results for CIN-afflicted tumors to our recent studies of the same tumor model without CIN (Dooling et al., 2023; Hayes et al., 2023), we find similar levels of IgG induction (e.g. ~100-fold above naive on average for IgG2a/c), similar increases in phagocytosis by sera opsonization (e.g. equivalent to anti-Tyrp1), and similar levels of suppressed tumoroid growth – including the variability. The gene discussed is TYRP1; the disease is cervical squamous intraepithelial neoplasia.