ADIPOQ and systemic lupus erythematosus: In contrast, while all four MR methods supported a null reverse causal relationship between resistin and SLE, the results of adiponectin were conflicting, namely, both IVW (OR = 0.971, P = 0.021) and weighted mode (OR = 0.971, P = 0.026) suggested a negative causal association; both MR‒Egger (OR = 1.017, P = 0.830) and weighted median (OR = 0.970, P = 0.142) supported a null reverse causal relationship.