LEP and systemic lupus erythematosus: At the significance level of 0.05, a sample size of 218,696 (the sample size of the FinnGen study specifically for SLE) provides a power of 0.44 to detect a causal risk of 1.5 (OR = 1.5) to develop SLE when the genetically predicted leptin/resistin/adiponectin level increases by one unit.