Tumor regions in phenotype cluster 1 are mainly comprised of genotype cluster 1 and mutation cluster 2, indicating an intermediate level of singly amplified EGFR and CDK4 cells, with a slightly higher frequency of TERTp-mutant cells compared with phenotype cluster 0 (Figure 3, B and C, and Supplemental Figure 4, A–C). This evidence concerns the gene EGFR and neoplasm.