Of note, 2 different types of immune cells were associated with the blood vessels in recurrent tumor tissue: the perivascular macrophages (“PVM”), expressing CD68, CD14, CD74, and CD163, corresponding with CD163+ immunostaining, and the SPP1-, CCL7-, and CEACAM1-expressing cells (“Immune”) — most likely tumor-infiltrating lymphocytes, which would correspond to the spatial positioning of CD8a+ immunostaining (Figure 5, A, E, and H). Here, SPP1 is linked to neoplasm.