The expression of HDAC3 was upregulated in various cancers, including COAD, READ, BRCA, and UCEC, while the expression of TIP60 was downregulated in these cancers, suggesting the possibility of a transcriptional repressor role of TIP60 in HDAC3 (Fig. 2A–C and Supplementary Fig. 1A-C). Here, HDAC3 is linked to cancer.