ERBB2 and breast cancer: Notably, Jensen et al. reported a case of long-term disease control with repeated CaEP treatments of cutaneous metastases in human epidermal growth factor receptor 2-positive (HER2-positive) breast cancer [16], and Falk H. et al. demonstrated the induction of a systemic immune response and distant tumour remission in a patient with melanoma, triggered by CaEP [12].