LRRK2 and Parkinson disease: First, our results show that a high PRS confers an additional risk of PD in LRRK2 G2019S carriers and earlier reported PD diagnoses, suggesting that PRS may be useful as an enrichment stratification biomarker for candidate optimization48,49 and symptom progression.50,51 Likewise, previous studies have similarly demonstrated relationships between PRS and PD status52 and age at onset52-55 further supporting the utility of PRS in PD clinical trials.