To further examine the impact of NLRP3 silencing on pyroptosis in CRC, we selected four CRC cell lines with differential NLRP3 expression to test drug‐induced pyroptosis: HCT116 and DLD1 with relatively high NLRP3 expression, and SW620 and LS174T with relatively low expression (Figure 1D). This evidence concerns the gene NLRP3 and colorectal carcinoma.