Single‐cell and bulk RNA sequencing analyses identified AOC3, COX11, COX17, COX19, CCS, CDKN2A, DLD, DLAT, and PDHB as CRGs predictive of CRC prognosis, revealing that the elevated expression of COX17 in CD4‐CXCL13 T cells mediated Treg infiltration and T cell exhaustion, while DLAT reversed T cell exhaustion and induced apoptosis, promoting antitumour immune activation.151. This evidence concerns the gene CCS and colorectal carcinoma.