In group II, which did not receive t-PA, patients with stroke caused by a cardiogenic embolism had significantly higher factor XIII-A levels 7 days after stroke onset (the second sampling) compared to patients with stroke of a non-cardiogenic cause (Me was 117.30% in cardiogenic stroke vs. 109.85% in non-cardiogenic stroke, respectively; p = 0.03). This evidence concerns the gene PLAT and Stroke.