In our study, we found that among patients treated with t-PA, the lowest factor XIII-A levels were found in the second sampling on day 7 in the most severe type of TACI stroke according to the OCSP scale, and there was a statistically significant difference (p = 0.04) compared to non-TACI stroke, which is in line with the results of Kohler et al. [26]. This evidence concerns the gene PLAT and stroke disorder.