In a murine model of renal fibrosis (UUO), EMT, hypoxia, apoptosis, genes downregulated in response to ultraviolet (UV) radiation, G2/M checkpoint of cell division cycle, and cell signaling (Notch and PI3K/Akt/mTOR) pathways were the most enriched in the MSigDB hallmark gene sets analysis (Figure 5A). The gene discussed is MTOR; the disease is renal fibrosis.