In addition, a His165Arg mutation (located in the cyt b5 domain of PGRMC1), identified in a heterozygous patient with premature ovarian failure, was shown to interfere with PGRMC1-mediated progesterone’s anti-apoptotic action and abolish binding to CYP7A1, important for the synthesis of bile acid and the regulation of cholesterol levels [164]. This evidence concerns the gene PGRMC1 and primary ovarian failure.