Enhancer of zeste homolog 2 (EZH2), a catalytic subunit of polycomb repressive complex 2 (PRC2), plays a key role in the epigenetic remodeling of MM through the trimethylation of Lys27 in histone 3 (H3K27me3) [16‒18] . Here, EZH2 is linked to Miyoshi myopathy.