Ephrin type-B receptor 4 (EPHB4), which belongs to receptor tyrosine kinases (RTKs) expressed extensively in variety of tumours such as lung cancer, colorectal cancer, and malignant soft tissue sarcoma, including rhabdomyosarcoma (RMS) (Kumar et al., 2009; Randolph et al., 2017). This evidence concerns the gene EPHB4 and colorectal cancer.