All six children with LP/P variants in the NF1 gene had a known Neurofibromatosis type 1 diagnosis; five were diagnosed with pilocytic astrocytoma of which two affecting the optic pathway; one with a high-grade astrocytoma with piloid features (Fig. 2a, Supplementary Table S3). This evidence concerns the gene NF1 and astrocytoma (excluding glioblastoma).