Among extracranial solid tumors, the ChiCaP diagnoses were more heterogeneous and included six children with retinoblastoma and pathogenic variants in RB1, three children with Wilms tumor and pathogenic variants in WT1, and one child each with pathogenic variants in DICER1, TP53, NF1, PMS2, ATM, ERCC5, FANCM, FBXW7, POLE, PRKAR1A, SH2D1A, and SMARCB1 (Fig. 2a and d). The gene discussed is POLE; the disease is Nephroblastoma.