In those with a pituitary microadenoma or equivocal findings on magnetic resonance imaging, one can proceed either directly to bilateral inferior petrosal sinus sampling (BIPSS), particularly if the adenoma is <6 mm, or take a noninvasive approach involving a combination of corticotropin-releasing hormone (CRH) and desmopressin stimulation tests alongside a whole body computed tomography imaging [1]. This evidence concerns the gene CRH and adenoma.