In our results, we found that zinc finger homeobox 4 (ZFHX4) co-occurs with TP53, MUC16, CSMD3, and GL1. It is worth noting that ZFHX4 was found to be upregulated in lung adenocarcinoma (LUAD) and was associated with a poor prognosis, as indicated by previous research (24). This evidence concerns the gene CSMD3 and lung adenocarcinoma.