However, although this seem to be the case in the colorectal cancer cell lines used in this study (p53 wild-type HCT116 was more sensitive than p53 mutated HT29), it does not hold true in glioblastoma, where the p53 wild-type A-172 cell line was more resistant than the p53 mutated LN-18. This evidence concerns the gene TP53 and colorectal cancer.