The use of mTOR inhibitors in combination with PDT increases the therapeutic effect.Photodynamic therapy using a new laser probe - composite optical fiber (COF), which allows precise laser illumination of the cancerous lesion and its simultaneous visualization.The possible use of PDT in dermatology in Europe has been updated. The recommendations include such diseases as: actinic keratosis, superficial and nodular basal cell carcinoma, and field cancerization. This evidence concerns the gene MTOR and actinic keratosis.