The effectiveness of the combination of 5-FU and PDT therapy is due to increased photosensitizer accumulation and p53 induction. A combination of both therapies was recommended.Efficacy of ALA-PDT in the treatment of vitiligo.A complication of ALA-PDT in the treatment of genital warts is more frequent infections among patients. Topical application of fusidic acid or mupirocin reduced the incidence of infection. Here, TP53 is linked to anogenital human papillomavirus infection.