have revealed that olfactory receptor 2 (Olfr2) interacts with TLR4 in vascular macrophages leading to NLRP3 inflammasomes activation via adenylate cyclase 3 (Adcy3) to drive atherosclerosis development, provides a new target for the prevention and treatment of atherosclerosis (35). The gene discussed is TLR4; the disease is atherosclerosis.